The future!

Dec. 1st, 2025 11:43 pm
james_davis_nicoll: (Default)
[personal profile] james_davis_nicoll
Tremble at the majesty of an AI designed house.

Read more... )

Step by Step

Dec. 1st, 2025 09:30 pm
billroper: (Default)
[personal profile] billroper
Apparently, I am going to write the design for a feature.

Now.

Let's see how this goes...

(New) Hire Education

Dec. 2nd, 2025 01:00 am
[syndicated profile] notalwaysworking_feed

Posted by Not Always Right

Read (New) Hire Education

Me: "Hey, [Boss], your schedule has James down as hiring the new guy."
Boss: "Yeah?"
Me: "Well, James started two weeks ago."
Boss: "Yeah?"

Read (New) Hire Education

Books read, late November

Dec. 1st, 2025 07:20 pm
mrissa: (Default)
[personal profile] mrissa
 

Sam Bloch, Shade: The Promise of a Forgotten Natural Resource. Interesting natural and social history--and present assessment--of the uses and needs of shade in sunny climates. Very much the sort of environmental study we need more of. Yay for this weird little book.

Meihan Boey, The Formidable Miss Cassidy. Structurally slightly odd but extremely good. "Some weirdos make friends; hijinks ensue" is one of my favorite shapes of plot, all the more so when there's more than one culture and a bunch of magic stuff going on. More from this author please.

Joseph J. Ellis, Revolutionary Summer: The Birth of American Independence. This is a good introductory book if you haven't already read a lot of stuff about the lead-up to the American Revolution. It's not actually one of the ones I'd put very high on my list if you have, but not everyone has.

Martín Espada, Jailbreak of Sparrows. I feel like these were longer and less punchy than his previous poems, but that could be genuine or could be a result of my own mood, hard to guess without more intense study. "Not my favorite Espada collection" is still a pretty good thing to be.

Margaret Frazer, The Stone Worker's Tale. Kindle. This is another of the mystery short stories in the same continuity as her novel series, slight but entertaining as most of them are. Sometimes you can watch mystery authors try to figure out some twist that will entertain them to write, and I think this was one of those times.

Howard W. French, The Second Emancipation: Nkrumah, Pan-Africanism, and Global Blackness at High Tide. This is a good place to go deeper on recent Ghanan history but also a good place to start if you don't feel like you know very much about 20th century West Africa. A very interesting read.

Greg Grandin, America, América: A New History of the New World and Kissinger's Shadow: The Long Reach of America's Most Controversial Statesman. I got interested in the first of these when I saw it in a bookstore, and it did not disappoint: it's a history of the US and Latin America, rather than focusing on the US's relationship with Europe as most such histories do. It was good enough that I requested the second one based on enjoying his work, and I'm not sure that "enjoy" is the right word for a whole book about Kissinger, but then I'm not sure it should be. Grandin's view of Kissinger is relentless, and I don't think he should have relented. And at least it's not terribly long, it doesn't make you spend more time with Kissinger than necessary to study his sociopolitical effects.

Adam Hochschild, Rebel Cinderella: From Rags to Riches to Radical, the Epic Journey of Rose Pastor Stokes. Hochschild is generally good, and I like to see closer-focus histories. Rose Pastor Stokes definitely is interesting enough for a whole book. I do feel like he wanted to be doing some things with her marriage as emblematic of things that didn't quite get there, but it's still worth the time.

Marina Lostetter, The Teeth of Dawn. The last in its series, and I finished it from momentum rather than enthusiasm for where the series went. I really liked the earlier ones, it's just this two-timeline narrative felt labored at points. I generally enjoy her ideas and writing and will be glad to see what else she does next.

Premee Mohamed, The First Thousand Trees. Another third volume. This one was a bit more genre-standard than its two predecessors, but well-executed on that, fitting it into the established worldbuilding and characters.

Trung Le Nguyen, Angelica and the Bear Prince. A sweet YA love story in graphic novel form. Cute to look at as well as cute storyline, won't take long.

Yasuhiko Nishizawa, The Man Who Died Seven Times. This is a time loop novel that's also a murder mystery, and I really liked that the looping character was attempting to prevent the murder in the process of solving it: how can I make this better. The twist in the ending was not entirely satisfying to me, and there was enough problematic alcohol use that even I, who don't usually flag that, feel like it's worth noting for people who really dislike that as an element in fiction.

Ellen Oh and Elsie Chapman, eds., A Thousand Beginnings and Endings. Retellings of Asian mythologies by Asian diaspora authors, somewhat varied but generally quite satisfying. I read this for book club, and it gave us a lot of happy fodder for discussion rather than the more annoyed kind we sometimes have.

Hache Pueyo, Cabaret in Flames. Discussed elsewhere.

Jonathan Slaght, Tigers Between Empires: The Improbable Return of Great Cats to the Forests of Russia and China. There's a lot about field work with Amur tigers in this. A lot. If you like that kind of nitty gritty about how the science gets done, good news, this is a book for you. I do like that sort of thing, so I was very pleased. My one complaint is that there is almost nothing about China and very little about the cross-cultural relationship work here. For having it in the subtitle, it's...really a Russian book. And that's okay! Just some clarity there.

Seamus Sullivan, Daedalus Is Dead. I thought this was going to be a completely different shape of thing, which is my fault and entirely on me. The cover and title made me think that Daedalus was going to be a metaphor. Nope! No metaphors here! Very literal retelling of Daedalus's experiences in life and afterlife! For some reason Sullivan decided that what he most wanted to do here was Daedalus as unreliable narrator in ways that have nothing at all to do with him as a technologist; there's stuff to be done with complicity in science/technology work, but very little of it was done here, most of Daedalus's flaws were...generic unpleasant dude flaws, I would say. It's written quite well, but I ultimately did not want to spend even a novella's worth of time with this character.

Ann Vandermeer and Jeff Vandermeer, eds., Sisters of the Revolution: A Feminist Speculative Fiction Anthology. Some very familiar, oft-reprinted stuff in here, plus some stuff I've never seen before. A very mixed bag, the full spectrum of my responses as well as the full spectrum of types of feminist SF.

Ellen Wayland-Smith, The Science of Last Things: Essays on Deep Time and the Boundaries of the Self. Wayland-Smith leans very heavily on similes in this essay collection, which often didn't work amazingly for me because the similes felt...fine? rather than genuinely illuminating. I feel like a cad saying that her best work was about her own mortality, but, well. Better than her worst work, I suppose? Still. This was fine enough but not a favorite.

Monday's Comic

Dec. 1st, 2025 06:25 pm
marycatelli: (Default)
[personal profile] marycatelli posting in [community profile] girlgenius_lair
Klaus, pay ATTENTION!

And Bang fulfills predictions gloriously.

The Manager Summoning Frequency

Dec. 1st, 2025 11:00 pm
[syndicated profile] notalwaysworking_feed

Posted by Not Always Right

Read The Manager Summoning Frequency

Me: "Where's [Manager]? I need him for an override."
Veteran Coworker: "Is he hiding in his office as usual?"
Me: "Literally the first place I looked."
Veteran Coworker: "Okay, let me show you a trick."

Read The Manager Summoning Frequency

Well, We Hope Starbucks Are Hiring!

Dec. 1st, 2025 09:00 pm
[syndicated profile] notalwaysworking_feed

Posted by Not Always Right

Read Well, We Hope Starbucks Are Hiring!

Me: "[New Hire], your shift started half an hour ago."
New Hire: "I know, but it's not my fault. You should have seen the traffic at the Starbucks drive-thru!"
Me: "You're late for your shift at a coffee place, because you were buying coffee at Starbucks?"

Read Well, We Hope Starbucks Are Hiring!

[syndicated profile] in_the_pipeline_feed

This is a good look at the current state of the art in creating peptidic binding ligands to protein targets out of thin air - well, “one-shot computation” is probably the more preferred term, but you get the idea. One expects this to start to be more feasible with such peptide ligands because of several factors: the modular nature of the peptides, for starters, combined with a limited number of amino acid building blocks both make the problem more bounded and discrete. And the remarkable successes of protein folding prediction software show that we have a reasonably good handle on peptide-structure-from-peptide-sequence in general, thanks to the huge pile of validated protein structural data. 

So let’s see how things go. The authors are using BindCraft, a freely available program which was originally developed for design of miniproteins. As the authors say, though, miniproteins are still rather different beasts than shorter peptides, not least because they’re (by definition) showing distinct tertiary structures, as opposed to the far more mobile peptides. It wasn’t clear if the BindCraft software would be able to produce useful small peptide binders at all, but the team set the parameters of the program to generate 10-20-mer peptides and had at it.

They started off with MDM2, a protein with high-quality structure data available, and they specified the known MDM2-p53 interface area as the part to design against. Note that this already gives you a couple of important steps to solving the problem (the partner has a stable structure, which you know in detail, and you also know just the region to target). They took 20 peptides suggestions and put them to the experimental test, finding that seven of them showed clear binding behavior, while the other 13 were weak at best (or just not binding at all, for the most part). The hits showed 65-165 nM binding, and six of them recapitulated a known hotspot triad of amino acids that have already been shown to be important for hitting this site. 

They then tried WDR5, another protein that’s had a substantial amount of work done on it, both for protein binders and for small molecules. It’s known to have two binding sites of interest, the WIN site and the MYC-binding one, and again you see that you’re starting with some advantages. The group generated 100 BindCraft-suggested peptides for each of those, with the top ten of each synthesized for some real experimental validation. Interestingly, though, none of the WIN-targeting candidates seemed to bind at all! On the other hand, six of the MYC-site targeting ones showed real binding, with moderate Kd values of 219 to 650 nM. Some of these do seem to be different than other binding motifs reported in the literature, which is a good sign. The team noted that many of the candidates were good ol’ alpha-helices, and selected one of these Myc-binding candidates for “peptide stapling” to lock that structure in place. Binding of the stapled candidate improved about six-fold to 39 nM, which seems to be good evidence. 

The last test was generating candidates against another binding interface that is well-described in structural biology, the PD-1/PD-L1 pair. But in this case, despite the structural knowledge and ability to point right at the key regions to target, none of the peptide candidates for either protein’s binding site seemed to show any activity at all.

I think this is a pretty honest assessment, and I very much appreciate the authors providing it instead of dwelling on the most successful parts. Overall, the software gets some things right and totally whiffs on others, and one of the things to note is that it’s not obvious which of those situations you’re going to find yourself in! But that’s generally the problem with purely computational approaches; you have to try things out and get your bearings. But when BindCraft can get its digital teeth into a problem, it does pretty well, and that’s creditable performance for a program that wasn’t really designed to be doing quite what it’s asked to be doing here. But that has to be balanced against the fact that (as mentioned) all three of these test cases were on proteins (and binding sites) that have been thoroughly characterized experimentally - your success rate would surely be lower if you try something like this on less-well-understood cases. 

So this glass is half full. There was a time when results like these would have still knocked people over, and it’s a testimony to how far computational protein design has come that now they fall into the “interesting” category instead. But given that BindCraft is freely available, does not need any serious computational resources (these runs were done on a system with a single GPU) and that the entry barriers to preparing proteins this size are low, I’d say this easily falls into the “Why not try it?” category if small protein ligands are your goal.

[syndicated profile] notalwaysworking_feed

Posted by Not Always Right

Read Do Not Password, Do Not Pass Go, Part 5

Me: "You need to enter the correct password."
User: "That is my password. I just had it changed."
She tries again: incorrect username or password.
Me: "Are you entering the correct username?"

Read Do Not Password, Do Not Pass Go, Part 5

Soup for breakfast

Dec. 1st, 2025 06:38 pm
[syndicated profile] sharonlee_feed

Posted by Sharon

Monday. Sunny, windy — let’s just agree to call it cold.

Breakfast was leftover tom-yum soup from lunch the other day. I think I have the name right. Lately, I’ve been trying to order one thing I’ve never had before, so instead of egg drop or wonton, I got this other soup. It’s sweet and sour, with chicken and veggies, garnished with peanuts. Makes a good breakfast on a cold morning.

Lunch was the last of the (unfrozen) Thanksgiving chicken with gravy and dressing. There’s a little bit of dressing left. It’s in no danger of getting wasted.

Trash and recycling is in the garage, meditating on its journey to the curb. Which may be delayed until next week, depending on when the storm starts tomorrow, and if the weatherbeans remain adamant in their 6-9-inch predictions. I don’t have to be anyplace until Wednesday morning, and I have plenty of milk for hot chocolate, not to say stuff to keep me occupied, so, yanno, I’ll be fine.

Finished watching Maigret last night (I had been going to finish the night before, but it was (sadly) clear to me how this was going to have to go down and I wasn’t up for Maigret finding out exactly what his roll of the dice had bought him.) Still, all’s well that ended well, though I fear for Louise and Jules as a couple.

As a writer, I do need to have a Word with Maigret’s writers. Guys? You don’t give a character a Defining Quirk, like, for instance HE DOESN’T DRIVE, and then, when that Quirk becomes inconvenient, suddenly! he DOES drive. Points off, writers. Do better going forward.

My to-do list says I have some phone calls and banking stuff to deal with, but what does it know? I’m gonna go play with glass for an hour, because I am reputedly An Adult. Also, having sat with the manuscript for four hours this morning, I need to think. Actually, I need to talk to Steve, but since that’s a non-starter, thinking it is, and so the glass.

How’s everybody this afternoon? Weather good? Whatcha watchin?

The Long Back Yard at 6:30 this morning:

Soup for breakfast

Dec. 1st, 2025 01:37 pm
rolanni: (Default)
[personal profile] rolanni

Monday. Sunny, windy -- let's just agree to call it cold.

Breakfast was leftover tom-yum soup from lunch the other day. I think I have the name right. Lately, I've been trying to order one thing I've never had before, so instead of egg drop or wonton, I got this other soup. It's sweet and sour, with chicken and veggies, garnished with peanuts. Makes a good breakfast on a cold morning.

Lunch was the last of the (unfrozen) Thanksgiving chicken with gravy and dressing. There's a little bit of dressing left. It's in no danger of getting wasted.

Trash and recycling is in the garage, meditating on its journey to the curb. Which may be delayed until next week, depending on when the storm starts tomorrow, and if the weatherbeans remain adamant in their 6-9-inch predictions. I don't have to be anyplace until Wednesday morning, and I have plenty of milk for hot chocolate, not to say stuff to keep me occupied, so, yanno, I'll be fine.

Finished watching Maigret last night (I had been going to finish the night before, but it was (sadly) clear to me how this was going to have to go down and I wasn't up for Maigret finding out exactly what his roll of the dice had bought him.) Still, all's well that ended well, though I fear for Louise and Jules as a couple.

As a writer, I do need to have a Word with Maigret's writers. Guys? You don't give a character a Defining Quirk, like, for instance HE DOESN'T DRIVE, and then, when that Quirk becomes inconvenient, suddenly! he DOES drive. Points off, writers. Do better going forward.

My to-do list says I have some phone calls and banking stuff to deal with, but what does it know? I'm gonna go play with glass for an hour, because I am reputedly An Adult. Also, having sat with the manuscript for four hours this morning, I need to think. Actually, I need to talk to Steve, but since that's a non-starter, thinking it is, and so the glass.

How's everybody this afternoon? Weather good? Whatcha watchin?

The Long Back Yard at 6:30 this morning:


[syndicated profile] notalwaysworking_feed

Posted by Not Always Right

Read Where We Break Down the Boxes And Our Feelings

Trainer: "So this is the breakdown area, as in we break down packaging and boxes for recycling."
Me: "I'm glad you explained that! For a moment, it sounded like you had a designated area for staff to have breakdowns."

Read Where We Break Down the Boxes And Our Feelings

Cabaret in Flames, by Hache Pueyo

Dec. 1st, 2025 11:27 am
mrissa: (Default)
[personal profile] mrissa
 

Review copy provided by the publisher.

Like Pueyo's debut, this is an extremely well-done example of something that is very, very much not my thing. This is another monsterfucking book! I am using that term as a genre term of art rather than a pejorative: there are guls, they eat human flesh, the main character ends up romantically/personally entangled with one despite or perhaps because of her complicated history.

There's vivid writing here--which if you are not interested in stories of human flesh being eaten is not necessarily going to appeal to you--and there are cultural touchstones I wish we saw more of in things published in the US. It's great to see a really Brazilian speculative novella--and the politics of contemporary Brazil give this speculative story weight and deep roots. It's done so well. It's just so beautifully written. But also, and crucially for me, it is body horror basically start to finish, so: approach with care, depending on your tastes.

Clarke Award Finalists 2024

Dec. 1st, 2025 10:59 am
james_davis_nicoll: (Default)
[personal profile] james_davis_nicoll
2024: Scutigera coleoptrata become established in the UK, a Trident missile suffers performance anxiety during a test and refuses to leave its sub, and Labour sweeps to victory in the General Election, with surprising little effect on the subsequent frequency of cruel and vindictive legislation.


Poll #33896 Clarke Award Finalists 2024
Open to: Registered Users, detailed results viewable to: All, participants: 16


Which 2024 Clarke Award Finalists Have You Read?

View Answers

In Ascension by Martin MacInnes
0 (0.0%)

Chain-Gang All-Stars by Nana Kwame Adjei-Brenyah
0 (0.0%)

Corey Fah Does Social Mobility by Isabel Waidner
1 (6.2%)

Some Desperate Glory by Emily Tesh
15 (93.8%)

The Mountain in the Sea by Ray Nayler
6 (37.5%)

The Ten Percent Thief by Lavanya Lakshminarayan
1 (6.2%)



Bold for have read, italic for intend to read, underline for never heard of it.

Which 2024 Clarke Award Finalists Have You Read?
In Ascension by Martin MacInnes
Chain-Gang All-Stars by Nana Kwame Adjei-Brenyah
Corey Fah Does Social Mobility by Isabel Waidner
Some Desperate Glory by Emily Tesh
The Mountain in the Sea by Ray Nayler
The Ten Percent Thief by Lavanya Lakshminarayan

In-Laws Follow No Laws

Dec. 1st, 2025 03:30 pm
[syndicated profile] notalwaysrelated_feed

Posted by Not Always Right

Read In-Laws Follow No Laws

Everyone's chatting away. I'm being ignored, as usual; not just in conversation, I often have to ask several times to get things passed to me. The only one being cool to me is my one uncle, who's USUALLY the most condescending man I've met up to that point; maybe he was just the only one that actually noticed my ever-worsening expression.

Read In-Laws Follow No Laws

[syndicated profile] notalwaysfriendly_feed

Posted by Not Always Right

Read Finnish Him Off With A Few Choice Words

My husband does not speak Finnish, but he understands it fairly well. He has been learning Swedish, the other national language of Finland. He orders his meal in English, and a stranger who seems to have something against foreigners overhears him.
Stranger: *In Finnish* “Learn Finnish, f***!”

Read Finnish Him Off With A Few Choice Words

2025.12.01

Dec. 1st, 2025 07:29 am
lsanderson: (Default)
[personal profile] lsanderson
'Tis the season for CO poisoning?
As the cold forces us indoors, Hennepin Healthcare officials are sounding the alarm on carbon monoxide poisoning, according to KARE 11. “Carbon monoxide, which is odorless, colorless and tasteless, can build up quickly in enclosed spaces and, if not treated promptly, can cause serious damage to the heart and brain or even be fatal.” Hennepin Healthcare reports 12 cases in November, “a number doctors describe as unusually high for this point in the cold-weather season.” Don’t miss the tips on how to reduce your risk of carbon monoxide poisoning at the end of the article.
https://www.kare11.com/article/news/health/hennepin-healthcare-sees-spike-in-carbon-monoxide-poisoning/89-4c01aaf2-8127-4701-ade1-3f0608b37089

Rising levels of hate forcing women out of Swedish public life, says equality agency
Country seen as champion of equal rights faces reckoning after senior politician says she felt compelled to quit
Miranda Bryant in Stockholm
https://www.theguardian.com/world/2025/dec/01/harassment-and-hate-forcing-women-out-of-swedish-politics

Cooking with gas gets more expensive as Americans face rising prices into 2026
Trump promised to cut consumers’ energy costs within his first year in office but gas price is up 4% on average
https://www.theguardian.com/us-news/2025/dec/01/gas-energy-prices

Airbus averts further travel disruption by fixing most jets hit by software glitch
French manufacturer had to ground thousands of planes at weekend but fewer than 100 now need update
Lauren Almeida
https://www.theguardian.com/business/2025/dec/01/airbus-averts-further-travel-disruption-by-fixing-most-jets-hit-by-software-glitch

Long-lost Rubens painting sells for $2.7m at auction
Auctioneer found the Flemish artist’s masterpiece – depicting a crucified Christ – in a Paris mansion as he was preparing for the property to be sold
Agence France-Presse
https://www.theguardian.com/artanddesign/2025/dec/01/long-lost-rubens-painting-sells-for-27m-at-auction

Power surge: law changes could soon bring balcony solar to millions across US
Tweaks to state laws mean many Americans will be able to benefit from small, simple plug-in solar panels
Oliver Milman
https://www.theguardian.com/us-news/2025/nov/30/balcony-solar-power-states-laws

From Dylan Thomas’ shopping list to a note from Sylvia Plath’s doctor: newly uncovered case files reveal the hidden lives of famous writers
Exclusive: Hardship grant applications to the Royal Literary Fund, including unseen letters by Doris Lessing and a note from James Joyce saying that he ‘gets nothing in the way of royalties’, show authors at their most vulnerable
Ella Creamer
https://www.theguardian.com/books/2025/nov/28/from-dylan-thomas-shopping-list-to-a-note-from-sylvia-plaths-doctor-newly-uncovered-case-files-reveal-the-hidden-lives-of-famous-writers

'A large amount of weirdness': The long, strange success of the Grateful Dead
Greg McKevitt
https://www.bbc.com/culture/article/20251127-the-long-strange-success-of-the-grateful-dead

Over 120,000 home cameras hacked in South Korea for 'sexploitation' footage
Gavin Butler
https://www.bbc.com/news/articles/cj01q6p7ndlo

Greek sheep and goat cull raises fears of feta cheese shortage
Kostas Koukoumakas
https://www.bbc.com/news/articles/cgex9d0212xo

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